pI: 8.1125 |
Length (AA): 151 |
MW (Da): 17196 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 3
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_130414)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G36980 | hypothetical protein |
Brugia malayi | Bm1_30440 | Small membrane protein |
Caenorhabditis elegans | CELE_Y74C10AL.2 | Protein Y74C10AL.2 |
Dictyostelium discoideum | DDB_G0281983 | TMEM50 family protein |
Drosophila melanogaster | Dmel_CG15012 | CG15012 gene product from transcript CG15012-RC |
Echinococcus granulosus | EgrG_000881800 | transmembrane protein 50B |
Echinococcus multilocularis | EmuJ_000881800 | transmembrane protein 50B |
Homo sapiens | ENSG00000142188 | transmembrane protein 50B |
Homo sapiens | ENSG00000183726 | transmembrane protein 50A |
Loa Loa (eye worm) | LOAG_09441 | hypothetical protein |
Mus musculus | ENSMUSG00000022964 | transmembrane protein 50B |
Mus musculus | ENSMUSG00000028822 | transmembrane protein 50A |
Oryza sativa | 4347235 | Os09g0453000 |
Oryza sativa | 4329713 | Os02g0566900 |
Onchocerca volvulus | OVOC65 | Small membrane protein related homolog |
Schistosoma japonicum | Sjp_0200170 | Transmembrane protein 50A, putative |
Schistosoma mansoni | Smp_041830 | small membrane protein related |
Schmidtea mediterranea | mk4.005226.00 | Small membrane protein related |
Trichomonas vaginalis | TVAG_226570 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_237740 | conserved hypothetical protein |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.